Roll back the years with transfusions of young blood
This combination of images provided by Lida Katsimpardi in May 2014 shows 3 D reconstructions of brain blood vessels in, from left, a young mouse, an old mouse, and an old mouse who was exposed to the blood of a young mouse.
Meanwhile, in parallel research, scientists at Harvard University discovered that a “youth protein” which circulates in the blood, is responsible for keeping the brain and muscles young and strong.
The protein, known as “GDF11″, is present in the bloodstream in large quantities when we are young but peters out as we age.
Although both the discoveries were made in mice, researchers are hoping to begin human trials in the next two to three years, in studies that could bring rapid improvements for human longevity and health.
“This should give us all hope for a healthier future,” said Prof Doug Melton, from Harvard’s department of stem cell and regenerative biology.
“We all wonder why we were stronger and mentally more agile when young, and these two unusually exciting papers actually point to a possible answer.
“There seems to be little question that GDF11 has an amazing capacity to restore aging muscle and brain function.”
Last year the team discovered that the protein could repair damaged hearts. But the new study showed that raising the levels of the GDF11 protein in older mice improved the function of every organ in the body.
Prof Lee Rubin, a Harvard stem cell biologist, added: “We do think that, at least in principal, there will be a way to reverse some of the decline of aging with a single protein. It isn’t out of question that GDF11, or a drug developed from it, might be worthwhile in [treating] Alzheimer’s disease.”
It is likely that the protein is at least partly responsible for the parallel finding by Stanford University that hollister young blood can reverse the signs of aging.
In the study, the blood of three month old mice was repeatedly injected into 1 hollister 8 month old mice near the end of their natural life span. The “vampire therapy” improved the performance of the elderly mice in memory and learning tasks. Structural, molecular and functional changes were also seen in their brains, the study published in the journal Science found.
If the same were seem in humans, it could lead to new therapies for recharging our aging brains and novel drugs for treating dementia.
“We’ve shown that at least some age related impairments in brain function are reversible. They’re not final,” said Dr Saul Vill hollister eda, of Stanford’s School of Medicine.
Ageing mice given eight infusions of young blood over three weeks improved their performance in mental tests such as locating a hidden platform in a water maze.
Evidence was also seen of new connections forming in the hippocampus, a brain region vital to memory and sensitive to aging.
Dendritic spines finger like extensions from the branches of neurons that are thought to play a role in memory formation also became more dense. Infusions of blood from other elderly mice had no effect, the study, published in the journal Nature, found.
“This could have been done 20 years ago,” said Dr Tony Wyss Coray, from Stanford University, the lead researcher. “You don’t need to know anything about how the brain works. You just give an old mouse young blood and see if the animal hollister is smarter than before.
“It’s just that nobody did it. Our data indicate that exposure of aged mice to young blood late in life is capable of rejuvenating synaptic plasticity and improving cognitive function.
“Future studies are warranted in aged humans and potentially those suffering from age related neurodegenerative disorders.”
Dr Eric Karran, from the dementia charity Alzheimer’s Research UK, said: “Although the treatments tested here rejuvenate certain aspects of learning and memory in mice, these studies are of unknown significance to humans.